To re-boot or not to re-boot. That is the question.
If Juliet detonated the Jughead bomb (reality aside), then if the Rules of Continuity are the same, she would have the same result as Desmond when he turned the fail safe key in the Hatch. The time line did not reset, skip or move. Desmond had conscious mind travel, but his body stayed in 2004 on the Island.
If the bomb went off, speculation is that it would re-set the 1977 time skippers back in sync with the rest of the 815ers, circa Jacob's death. It would be a literary cue to get all the characters back on the same page to resolve their interpersonal conflicts, but it would not resolve the underlying Island supernatural properties. We still do not know what are the Island rules. You would think that they would apply equally to Desmond and to Juliet. If that is true, then Juliet would survive the explosion-implosion at the drill site, but transport her memories to her off-island self which in turn, would cause her not to go to the Island in 2001. Her new mission could be to stop the other prisoners (the 815ers) from not boarding the plane that crashes in 2004, and thus changing history.
Even that premise does not help to resolve the Big Questions. It almost serves to erase the past five seasons of story lines and personal conflicts in exchange for one final sprint to the finish line.