"They're coming!"
This was part of the cliff hanger story line from S5. Ben has just stabbed Jacob in the base of the statue, and Jacob gives New Locke (MIB) the warning that THEY are coming. New Locke (MIB) seems alarmed by the warning. Many questions, but the most important:
Who are THEY? The term means two or more people. One could quickly imagine Widmore, but his soldiers of fortune already came to the Island are were defeated. In addition, Widmore hinted to Locke that there was a war on the horizon which would mean outsiders attempting to take control of the Island. Could it be character(s) we already know, like Mrs. Hawking and the Brother from Desmond's monastery? In a religious context, could it be angels? In a reversal, could it be underworld demons? With the increasing number of Egyptian symbols, could it be the return of the last time traveling Pharaoh? What would the natives or Others fear the most? A return of the military? The return of the Dharma? More random people falling out of planes?