What is the smoke monster?
It could have always existed on the island, as the original protector of the light source.
It could have been "awakened" or "released" when MIB's body was put into the light cave.
It could have been created from MIB's soul.
The monster appears to have electromagnetic properties (electric flashes; scanning).
It has the ability to shape shift matter into human forms but cannot create human beings (no blood when Flocke stabbed with knife, but Flocke "sweats" while in the jungle).
Things that do not affect it, either as the smoke monster or Flocke:
air, light, darkness, water, fire, earth, bullets, knives, electromagnetism, radiation (from the cave).
The only thing that does affect it: sonic fence (sound waves).
If the smoke monster is an electromagnetic being, electromagnetic waves is a part of its construction; sound waves must somehow "disrupt," "cancel" or "refract" its matter in a destructive manner. So the only possible solution would be blast Flocke at point blank range with a sonic boom? (Like a portable boom box playing Driveshaft??)