Throughout human existence, mankind has been aware of a few absolute truths: people are born and people die.
It is how one perceives life is what has changed over the tens of thousands of years. In the past, ancient cultures mostly saw their lives in the cycles of Nature. Every year, like the seasons, would follow birth, harvest, death and rebirth. But in modern societies, the view is that life is a linear plane where each year of existence is another marker on a ruler.
Also, it is interesting that ancient cultures believed that there were present gateways from their creator gods to themselves on Earth. Ancient people looked to the stars in the heavens as the source of their own lives, including seeing the Milky Way as a portal to everlasting life. Modern religions have adapted some of those past beliefs into a system of morality, where the human spirit lives on after mortal death on Earth, to be transported to a new realm of existence (heaven or hell).
But in this modern view, there is debate on whether there are intermediate steps in the transition from human to soul spirit. The ancient Egyptians believed that a human soul is divided at death so one part has to suffer judgment through a long, dangerous journey through the underworld with the hope to be reunited with its other part in paradise. Modern theology tends to state that if a person is good in his or her life, they will be rewarded in some fashion: external bliss in heaven in angelic form or reborn as another person or life form on Earth.
It is the transitory nature of life to death to potential rebirth that keeps the human mind from going completely mad at the prospect of nothingness at the end game.
So how could LOST fit into this existence time line? The island was supposed to be the place of life, death and rebirth. It did not have the physics of an actual Earth island, so it is assumed that it is either a supernatural place or overlaps into another dimension of time-space. In other words, the island could be the space between human life and death.
For some viewers, that intermediate place makes sense. The characters pre-815 back stories show edtheir lives, troubles and sins. The sideways world showed the waiting room in the after life. The bridge between the two different existences had to be the island. It goes to show then that the characters could still be "alive" on the transitional island realm, but not able to "move on" to the after life unless certain conditions were met.
If you then view the island as a land of make believe, not of Earth but its own unique sphere of existence, it is easier to gloss over the factual inaccuracies or inconsistent story plot points because none of those really matter in a place which has no normal rules.