IS IT POSSIBLE?

Is it possible that someone will be able to take the LOST story and re-work it into a unified climax of the desperate, tangential plots?

Yes, if someone took the time and effort to re-edit the series into chronological order (which I have not seen except the first two hours), then in the buried archeological pit of the scripts there is a lost treasure that ties everything together.

In order to tie every piece of the LOST puzzle together, one will have to consider suspending belief but not to the point of irrational McGuffins. The best science fiction has at its core science principles "extended" by theoretical advancement.

For example, is it possible to survive a mid-air plane separation at 30,000 feet? No. Is it possible to survive a free fall from 9,000 feet (as shown in the Others centric episode showing the crash from Ben's perspective)? Perhaps, but unlikely. Is it possible that since Desmond did not enter the numbers promptly, causing a system failure and release of electromagnetic energy, that the unique EM properties could have acted as parachutes or pillows for the survivors who landed alive on the island? That could be a possibility. With the Desmond error causing an electromagnetic incident, is it possible that based on the FDW's ability to harness the EM to shift the island in time and space, that the EM discharge selectively carried the survivors into a different time, space or dimension (including the afterlife as in Dante's Inferno)? That could be a greater possibility since it links together more key elements of the story mythology.

And this is how it could be possible to use the story clues, stated science principles, island factors, and cause-and-effect relationships to build a detailed model of what actually happened to the characters in a unified story that would tie all the loose ends.

In order to accomplish something this grand, one will need to extract the core mythology elements and make them core building blocks from which "the answers" can logically be found for the show's mysteries. There truly needs to be story rules to avoid continuity issues.

It will be complex, confusing and frustrating. For example, the writers had no consistent concept of "time."  It was linear. Then it was circular. Then it was classified as a moving stream. Each one of these time concepts is different. And when the writers dropped the bomb in the sideways world having "no past, no present, no future, but just now," how does one deal with characters moving forward in a space with no time at all? The "now" is not the present because the present represents the future minus the past. Unless the after life principle is that souls live in a null space, then why would they appear to live "normal" lives along a progressive time line?

Even if one can forge through the serious stuff, can one weave an explanation that would appease, delight and answer all the questions of the die-hard fan? Probably not. And that is why no one has really tried to tackle this ambitious project.