The BBC ponders this:
Don't panic, but our planet is doomed. It's just going to take a while. Roughly 6 billion years from now,the Earth will most likely be vaporized when the sun dies and expands into a red giant that engulfs Earth.
But
the Earth is just one planet in the solar system, the Sun is just one
of hundreds of billions of stars in the galaxy, and there are hundreds
of billions of galaxies in the observable universe. What's in store for
all of that? How does the universe end?
There was The Big End Question asked in LOST when the alleged motivation to stop Flocke was that if he escaped the island, the world would be destroyed. But what world?
We assumed it was Earth. But how?
Flocke was a smoke monster, an intelligent being that could shape shift matter, take human form and steal human memories. It may have lived on fear. It had emotions that anger, rage to violence.
If the island was its prison, a containment field of electromagnetic energy, would Flocke's release into the universe or solar system expand its smoke powers to levels that would destroy the vacuum of space as we understand it?
We were told that Flocke escaping would destroy the planet. Could Flocke's mere presence in the atmosphere or orbit could shape shift, change or destroy the planet? If it had that much power to begin with, how could the tiny island contain it?
Of course, the destruction of the universe could have been a lie. A con. A reason Jacob had to recruit and keep his candidates at bay. But it seemed that there was a real possibility that Flocke would harm anyone or anything to get his way. But we never really knew where Flocke wanted to go.
Some rationalize that Smokey could be Satan, a fallen angel, whose only goal was to leave his personal hell on Earth to return to Heaven. But if he is not welcome in Heaven, then the disruption of the afterlife world would happen. Could that be the ripple in time and space (between dimensions) that the island's "cork" was really trying to keep steady? A parallel universe could collapse or engulf our present universe like a dying sun? If that was spelled out clearly in the series, we could probably get a greater purpose in the final showdown between the candidates and Flocke. This seems to be an important plot point that should have been explained to the viewers.
So we don't know if the "death" of Flocke was really the end of danger or merely the trigger to switch planes of parallel universes. If one believes in parallel universes, each of us has a doppelganger in that other world. But through experience, chance, free will and personal decisions, our doppelgangers can be different people. If the release of energy (memories) from one universe to another could be just as catastrophic, the sideways world view becomes clearer. If the main characters began to "awake" with memories from the wrong universe - - - that could destroy the belief system in their universe. It could disrupt the natural flow of energy, time and space that separates universes much like the different currents in the layers of an ocean.
We don't know if the awakening of the characters in the afterlife was just the end of a journey, or the actual cause of destruction of an entire universe.