He remarked that at the end of the day, relationships is what really changes us. We change because our behavior is impacting someone or something in a way that we don't or they don't like. When he watched the last episode of LOST, he believed the show was not being about a problem or puzzle to be solved, but about the people who were stranded on that island and how they lived and learned together.
He understood that many fans felt the producers of Lost could have or should have tied together the entire plot line. What happened to Walt? What was the meaning of Jacob and his family? In the end, he opined that the only way to end such a confusing story is the same way we manage our confusing lives, "to embrace relationships." That's what he said he did when he watched the show; he mourned, cheered, puzzled and ultimately came out without real answers, but connected to their experience.
He acknowledged that the ending placed fans into two camps. One group is frustrated. They are angered by what the writers have "done to them;" confused by the end that didn't provide them with the answers they wanted, they complain that they were lead astray. The other group talks about the beauty of the end, the way the last frame had us watch Jack's eye close the same way it opened. We are left with the circular beauty of life.